Targretin - Talk Medical

Generic Name: bexarotene

Brands: Targretin

What is the most important information I should know about Targretin?

· Avoid prolonged exposure to sunlight or artificial ultraviolet light (e.g. sunlamps). Targretin may increase the sensitivity of your skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

· Do not take Targretin if you are pregnant or if you could become pregnant. Targretin is in the FDA pregnancy category X. This means that Targretin will cause birth defects in an unborn baby. You must take a pregnancy test and have negative results within one week before starting treatment with Targretin, and a pregnancy test should be repeated monthly during treatment. Targretin should be started on the second or third day of a normal menstrual period. Also, you will need to use two reliable forms of birth control at the same time for one month before starting treatment with Targretin, during treatment with Targretin, and for at least 1 month following the end of your treatment. If you become pregnant, stop using birth control, or miss your menstrual period, immediately stop taking Targretin and notify your doctor. Men taking Targretin with sexual partners who are pregnant, possibly pregnant, or who could become pregnant, must use condoms during sexual intercourse while using Targretin and for at least one month after the last dose of Targretin.

· Swallow each capsule whole. Do not chew them, dissolve them in liquid, or allow them to dissolve in your mouth.

· Your doctor will want to monitor the levels of lipids (triglycerides and cholesterol) and thyroid hormones in your blood periodically during treatment with Targretin. Treatment may be necessary if your cholesterol or triglyceride levels become elevated, or if your thyroid hormone levels are low.

· Grapefruit and grapefruit juice may interact with Targretin. The interaction could have potentially dangerous effects. Discuss the use of grapefruit and grapefruit juice with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

What is Targretin ?

· The exact way Targretin works is unknown, but it is believed to inhibit the growth of tumor cells.

· Targretin is used to treat skin lesions of cutaneous T-cell lymphoma (CTCL) in patients who have not responded to or not tolerated other therapies.

· Targretin may also be used for purposes other than those listed in this medication guide.

Who should not use Targretin ?

· Do not take Targretin without first talking to your doctor if you ·are allergic to other retinoids such as isotretinoin (Accutane), acitretin (Soriatane), etretinate (Tegison), or tretinoin (Vesinoid); ·have or ever have had pancreatitis (inflammation of the pancreas); ·have high triglyceride levels in your blood; ·have diabetes mellitus; ·have or ever have had gall bladder disease; ·have or ever have had liver disease; ·regularly drink alcohol; ·are taking gemfibrozil (Lopid); ·are taking any prescription medication especially for fungal infections, bacterial infections, diabetes, or seizures; or, ·eat grapefruit or drink grapefruit juice.

· You may not be able to take Targretin, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions, or are taking any of the medications listed above.

· It is not known whether Targretin passes into breast milk. Do not take Targretin without first talking to your doctor if you are breast-feeding a baby.

How should I use Targretin ?

· Take Targretin exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

· Your doctor will tell you how many Targretin capsules to take each day. Take your daily dose of Targretin all at once. Take Targretin once a day with or immediately following a meal.

· Swallow each capsule whole. Do not chew them, dissolve them in liquid, or allow them to dissolve in your mouth.

· Do not take any Targretin capsules after the expiration date printed on the label.

· If any Targretin capsules are broken or leaking, do not touch the capsules or the contents and notify your pharmacist immediately. If the contents of a broken capsule get on your skin, immediately wash the area with soap and water and notify your physician.

· It may take many weeks of treatment to see the effects of this drug. Do not stop taking Targretin if you do not see results immediately. Some patients treated with Targretin see improvement within the first several weeks of treatment, however most patients require several months or more of treatment to improve.

· Store Targretin at room temperature away from moisture and heat.

What happens if I miss a dose?

· Take the missed dose, with food, as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

· Seek emergency medical attention.

· Symptoms of a Targretin overdose are unknown.

What should I avoid while using Targretin ?

· Vitamin A may increase side effects when taking Targretin. Limit your use of vitamin A supplements to not more than the recommended daily allowance (RDA) of 4000 to 5000 International Units (IU) a day. If you take vitamins, check the label to see how much vitamin A they contain. If you are not sure, ask your doctor or pharmacist.

What are the possible side effects of Targretin ?

· If you experience any of the following serious side effects, stop taking Targretin and seek emergency medical attention: ·an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); or ·symptoms of pancreatitis (inflammation of the pancreas) such as persistent nausea, vomiting, and abdominal or back pain.

· Other, less serious side effects may be more likely to occur. Continue to take Targretin and talk to your doctor if you experience: ·an increase in fats in the blood (blood lipids) such as cholesterol or triglycerides (blood tests will detect this); ·a underactive thyroid (blood tests will detect this); ·blood problems; ·headache; ·fatigue; ·weakness or loss of strength; ·swelling; ·rash; ·dry skin; ·infections; ·nausea; or ·diarrhea.

· Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Targretin ?

· Do not take Targretin without first talking to your doctor if you are taking any of the following drugs: ·gemfibrozil (Lopid); ·ketoconazole (Nizoral) or itraconazole (Sporanox); ·erythromycin (E.E.S., E-Mycin, Eryc, Ery-Tab, Ilosone, others); ·rifampin (Rifadin, Rimactane); ·phenobarbital (Luminal, Solfoton); ·phenytoin (Dilantin, others); or ·a diabetes medicine such as insulin, glipizide (Glucotrol), glyburide (Diabeta, Micronase, Glynase), chlorpropamide (Diabinese), tolbutamide (Orinase), tolazamide (Tolinase), glimepiride (Amaryl), rosiglitazone (Avandia), pioglitazone (Actos), metformin (Glucophage), and others.

· You may not be able to take Targretin, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

· Drugs other than those listed here may also interact with Targretin. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

· Your pharmacist has additional information about Targretin written for health professionals that you may read.

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